Junctional Membrane Uncoupling

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Junctional Membrane Uncoupling

The permeability of the membrane surfaces where cells are in contact (junctional membranes) in Chironomus salivary glands depends on Ca(++) and Mg(++). When the concentration of these ions at the junctional membranes is raised sufficiently, these normally highly permeable membranes seal off; their permeability falls one to three orders, as they approach the nonjunctional membranes in conductanc...

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Junctional Membrane Uncoupling Permeability transformations at a cell membrane junction

The permeability of the membrane surfaces where cells are in contact (junctional membranes) in Chironomus salivary glands depends on Ca ++ and Mg++. When the concentration of these ions at the junctional membranes is raised sufficiently, these normally highly permeable membranes seal off; their permeability falls one to three orders, as they approach the nonjunctional membranes in conductance. ...

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A little gap junctional uncoupling too much.

See article by Pollard et al. [15] (pages 381 –392) in the ischemic zone and with corresponding heterogeneous this issue. depressed excitability [9]. The mechanism of the 1B phase of arrhythmias is as of Ventricular fibrillation (VF) in the setting of acute today not fully understood. Kaplinsky et al., in the seminal myocardial ischemia and infarction remains an enormous paper mentioned above, ...

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Acute ischemia-induced gap junctional uncoupling and arrhythmogenesis.

Sudden cardiac death forms a major cause of mortality. Myocardial ischemia-induced ventricular fibrillation (VF) is frequently the underlying mechanism. Ventricular arrhythmias arise in two distinct phases during the first hour of ischemia. The first, the 1A phase, has been extensively studied, and few studies relate to the 1B phase. The latter is associated with intercellular electrical uncoup...

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Gap junctional uncoupling plays a trigger role in the antiarrhythmic effect of ischaemic preconditioning.

OBJECTIVE The aim of this study was to determine whether uncoupling of gap junctions (GJ) prior to ischaemia would modify the antiarrhythmic effect of ischaemic preconditioning (PC) in a canine model of ischaemia/reperfusion. METHODS Twenty control dogs, anaesthetised with chloralose and urethane, were thoracotomised and subjected either to a 25 or a 60 min occlusion of the left anterior desc...

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ژورنال

عنوان ژورنال: Journal of General Physiology

سال: 1967

ISSN: 1540-7748,0022-1295

DOI: 10.1085/jgp.50.7.1865